GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs425105 | 1 | rs60652743 | chr19:47205707 | PRKD2 | chr19:47177574-47220384:- | 0.21 | 5.13 | 4.18E-7 | Type 1 diabetes |
| THCA | cis | rs428445 | 1 | rs60654041 | chr20:55077917 | C20orf43 | chr20:55043647-55093942:+ | 0.28 | 7.45 | 4.42E-13 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs60654041 | chr20:55077917 | CSTF1 | chr20:54967427-54979582:+ | 0.16 | 3.37 | 0.00081 | Refractive astigmatism |
| THCA | cis | rs7679 | 1 | rs6065906 | chr20:44554015 | WFDC3 | chr20:44402847-44420547:- | -0.28 | -4.15 | 3.95E-5 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs12748152 | 1 | rs60659886 | chr1:26994245 | PIGV | chr1:27114455-27124886:+ | -0.32 | -4.08 | 5.32E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs12748152 | 1 | rs60659886 | chr1:26994245 | ZDHHC18 | chr1:27153201-27182207:+ | 0.93 | 11.37 | 1.15E-26 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs6012564 | 1 | rs6066968 | chr20:47727341 | ARFGEF2 | chr20:47538275-47653229:+ | -0.13 | -4.09 | 5.13E-5 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066968 | chr20:47727341 | CSE1L | chr20:47662838-47713484:+ | 0.41 | 10.23 | 2.32E-22 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066975 | chr20:47750377 | ARFGEF2 | chr20:47538275-47653229:+ | 0.12 | 3.73 | 0.000215 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066975 | chr20:47750377 | CSE1L | chr20:47662838-47713484:+ | -0.41 | -9.84 | 6.48E-21 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066977 | chr20:47755075 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.68 | 0.000263 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066977 | chr20:47755075 | CSE1L | chr20:47662838-47713484:+ | 0.4 | 9.98 | 2.0E-21 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066978 | chr20:47755742 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.83 | 0.000145 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066978 | chr20:47755742 | CSE1L | chr20:47662838-47713484:+ | 0.41 | 10.13 | 5.59E-22 | Anger |
| THCA | cis | rs6012564 | 1 | rs6066982 | chr20:47763558 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.94 | 9.39E-5 | Anger |